Publication | IEEE Transactions on Visualization and Computer Graphics 2018

PhenoLines

Phenotype Comparison Visualizations for Disease Subtyping via Topic Models

Abstract

PhenoLines: Phenotype Comparison Visualizations for Disease Subtyping via Topic Models

Michael Glueck, Mahdi Pakdaman Naeini, Finale Doshi-Velez, Fanny Chevalier, Azam Khan, Daniel Wigdor, Michael Brudno

IEEE Transactions on Visualization and Computer Graphics 2018

PhenoLines is a visual analysis tool for the interpretation of disease subtypes, derived from the application of topic modelsto clinical data. Topic models enable one to mine cross-sectional patient comorbidity data (e.g., electronic health records) and constructdisease subtypes—each with its own temporally evolving prevalence and co-occurrence of phenotypes—without requiring alignedlongitudinal phenotype data for all patients. However, the dimensionality of topic models makes interpretation challenging, and defacto analyses provide little intuition regarding phenotype relevance or phenotype interrelationships. PhenoLines enables one tocompare phenotype prevalence within and across disease subtype topics, thus supporting subtype characterization, a task that involvesidentifying a proposed subtype’s dominant phenotypes, ages of effect, and clinical validity. We contribute a data transformation workflowthat employs the Human Phenotype Ontology to hierarchically organize phenotypes and aggregate the evolving probabilities producedby topic models. We introduce a novel measure of phenotype relevance that can be used to simplify the resulting topology. The designof PhenoLines was motivated by formative interviews with machine learning and clinical experts. We describe the collaborative designprocess, distill high-level tasks, and report on initial evaluations with machine learning experts and a medical domain expert. Theseresults suggest that PhenoLines demonstrates promising approaches to support the characterization and optimization of topic models.

Download publication

Related Resources

Article

2023

From Steps to Stories with The Bentway

Check out how we’re using data to tell stories with The Bentway…

Publication

2023

Tesseract: Querying Spatial Design Recordings by Manipulating Worlds in Miniature

New immersive 3D design tools enable the creation of spatial design…

Project

2019

Command Usage Arc Diagrams

Exploring and analyzing a database of over 60 million commands issued…

Project

2009

Large Displays

Exploring design solutions to the unique interaction challenges which…

Get in touch

Something pique your interest? Get in touch if you’d like to learn more about Autodesk Research, our projects, people, and potential collaboration opportunities.

Contact us